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dc.contributor.authorHinchliffe, Alice
dc.contributor.authorAlguacil Ojeda, Juan 
dc.contributor.authorTurner, Michelle C.
dc.identifier.citationHinchliffe, A., Kogevinas, M., Molina, A. J., Moreno, V., Aragonés, N., Castaño-Vinyals, G., Jiménez Moleón, J. J., Gómez Acebo, I., Ederra, M., Amiano, P., Molina-Barceló, A., Fernandez-Tardon, G., Alguacil, J., Chirlaque, M.-D., Hernández-Segura, N., Pérez-Gómez, B., Pollan, M., & Turner, M. C. (2023). Association of occupational heat exposure and colorectal cancer in the MCC-Spain study. In Scandinavian Journal of Work, Environment & Health (Vol. 49, Issue 3, pp. 211–221). Scandinavian Journal of Work, Environment and Health.
dc.identifier.issn1795-990X (electrónico)
dc.description.abstractObjective Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest in potential chronic health effects of occupational heat exposure, including cancer risk. We examined potential associations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case–control study. Methods We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls. The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupations of participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure and duration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression adjusting for potential confounders. Results Overall, there was no association of ever, compared with never, occupational heat exposure and CRC (OR 1.09, 95% CI 0.92–1.29). There were also no associations observed according to categories of cumulative exposure or duration, and there was no evidence for a trend. There was no clear association of ever occupational heat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positive associations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI 1.09–3.03) and duration (OR 2.89, 95% CI 1.50–5.59) as well as some evidence for a trend (P<0.05). Conclusion Overall, this study provides no clear evidence for an association between occupational heat exposure and CRC.es_ES
dc.description.sponsorshipThe study was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundación Marqués de Valdecilla (API 10/09), the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional government of the Basque Country, the Consejería de Sanidad de la Región de Murcia, the European Commission grants FOOD-CT-2006–036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the Catalan Government DURSI grant 2014SGR647, the support of the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia (2017SGR1085), the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. MCT is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by the European Social Fund. We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. Statistical assistance provided by Ana Espinosa Morano was greatly appreciated.es_ES
dc.publisherNordic Association of Occupational Safety and Health (NOROSH)es_ES
dc.relation.isversionofPublisher’s version
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherHealth effectes_ES
dc.subject.otherHeat stresses_ES
dc.subject.otherOccupational healthes_ES
dc.titleAssociation of occupational heat exposure and colorectal cancer in the MCC-Spain studyes_ES
dc.subject.unesco3212 Salud Publicaes_ES
dc.subject.unesco32 Ciencias Médicases_ES

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