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dc.contributor.authorHinchliffe, Alice
dc.contributor.authorAlguacil Ojeda, Juan 
dc.contributor.authorBijoux, Wendy
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorMenegaux, Florence
dc.contributor.authorParent, Marie-Elise
dc.contributor.authorPérez Gómez, Beatriz
dc.contributor.authorUuksulainen, Sanni
dc.contributor.authorTurner, Michelle C.
dc.identifier.citationHinchliffe, A., Alguacil, J., Bijoux, W., Kogevinas, M., Menegaux, F., Parent, M.-E., Pérez Gomez, B., Uuksulainen, S., & Turner, M. C. (2023). Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies. In Environmental Research (Vol. 216, p. 114592). Elsevier BV.
dc.description.abstractBackground: Heat exposures occur in many occupations. Heat has been linked to key carcinogenic processes, however, evidence for associations with cancer risk is sparse. We examined potential associations between occupational heat exposure and prostate cancer risk in a multi-country study. Methods: We analysed a large, pooled dataset of 3142 histologically confirmed prostate cancer cases and 3512 frequency-matched controls from three countries: Canada, France, and Spain. Three exposure indices: ever exposure, lifetime cumulative exposure and duration of exposure, were developed using the Finnish Job- Exposure Matrix, FINJEM, applied to the lifetime occupational history of participants. We estimated odds ratios (ORs) and 95% confidence intervals (CIs), using conditional logistic regression models stratified by 5-year age groups and study, adjusting for potential confounders. Potential interactions with exposure to other occupational agents were also explored. Results: Overall, we found no association for ever occupational heat exposure (OR 0.97; 95% CI 0.87, 1.09), nor in the highest categories of lifetime cumulative exposure (OR 1.04; 95% CI 0.89, 1.23) or duration (OR 1.03; 95% CI 0.88, 1.22). When using only the Spanish case-control study and a Spanish Job Exposure Matrix (JEM), some weakly elevated ORs were observed. Conclusions: Findings from this study provide no clear evidence for an association between occupational heat exposure and prostate cancer risk.es_ES
dc.description.sponsorshipThe study was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on October 11, 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundación Marqués de Valdecilla (API 10/09), the Junta de Castilla y León (LE22A10–2), the Consejería de Salud of the Junta de Andalucía (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional Government of the Basque Country, the Consejería de Sanidad de la Región de Murcia, the European Commission grants FOOD-CT-2006–036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the Catalan Government DURSI grant 2014SGR647, the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. MCT is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by the European Social Fund. We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX 2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. PROtEuS was supported financially through grants from the Canadian Cancer Society (grants no. 13149, 19,500, 19,864 and 19,865), the Cancer Research Society, the Fonds de Recherche du Québec-Santé (FRQS), FRQSR Réseau de recherche en santé environnementale, the Ministère du Développement économique, de l’Innovation et de l’Exportation du Québec, and the Canadian Institutes of Health Research (grant no. 159704). The EPICAP Study was funded by Ligue nationale contre le cancer, Ligue contre le cancer du Val-de-Marne, Fondation de France, Agence nationale de securite sanitaire de l’alimentation, de l’environnement et du travail (ANSES).es_ES
dc.relation.isversionofPublisher’s version
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherCase-control studyes_ES
dc.subject.otherHeat stresses_ES
dc.subject.otherOccupational heat exposurees_ES
dc.subject.otherPooled analysises_ES
dc.subject.otherProstate canceres_ES
dc.titleOccupational heat exposure and prostate cancer risk: A pooled analysis of case-control studieses_ES
dc.subject.unesco32 Ciencias Médicases_ES

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