Background: Prior research has documented the protective role of the 5Cs of Positive
Youth Development (PYD) on adjustment problems, such as depressive symptoms. Nonetheless,
more research is needed, especially in non-US contexts. The main objective of the present study was
to assess associations between the 5Cs and depressive symptoms in Peru and Spain, considering
gender differences across contexts. Methods: Cross-sectional data was collected from undergraduate
students from Peru [n = 250] and Spain [n = 1044]. Results: The results revealed significant negative
associations of Competence, Confidence, Character and Connection with depressive symptoms, while
Caring was positively and significantly related to depressive symptoms in both samples. Regarding
gender differences, female undergraduates in both samples reported high levels of Caring, while
Competence was predominant among males compared to females in both countries. Likewise,
higher scores in Competence and Confidence were registered among Peruvian male undergraduates
compared to Spanish students, while Caring and Character were more prevalent in Spanish female
undergraduates compared to Peruvian students. Conclusions: These findings confirm the importance
of targeting the 5Cs of PYD alongside the role of gender and country context in intervention programs,
put together to address the mental health of students in Peru and Spain.