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dc.contributor.authorArias Borrego, Ana 
dc.contributor.authorCallejón Leblic, María Belén 
dc.contributor.authorCatalayud, Marta
dc.contributor.authorGómez Ariza, José Luis 
dc.contributor.authorCollado, María Carmen
dc.contributor.authorGarcía Barrera, Tamara
dc.identifier.citationArias-Borrego, A., Callejón-Leblic, B., Calatayud, M., Gómez-Ariza, J. L., Collado, M. C., & García-Barrera, T. (2019). Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota – current analytical methodologies. Expert Review of Proteomics, 16(10), 805–814.
dc.identifier.issn1744-8387 (electrónico)
dc.description.abstractIntroduction: Selenium plays many key roles in health especially in connection with cancer and neurodegenerative diseases. However, it needs to be appreciated that the essentiality/toxicity of selenium depends on both, a narrow range of concentration and the chemical specie involved. In this context, selenoproteins are essential biomolecules against these disorders, mainly due to its antioxidant action. To this end, analytical methodologies may allow identifying and quantifying individual selenospecies in human biofluids and tissues. Areas covered: This review focus on the role of selenoproteins in medicine, with special emphasis in cancer and neurodegenerative diseases, considering the possible link with gut microbiota. In particular, this article reviews the analytical techniques and procedures recently developed for the absolute quantification of selenoproteins and selenometabolites in human biofluids and tissues. Expert commentary: The beneficial role of selenium in human health has been extensively studied and reviewed. However, several challenges remain unsolved as discussed in this article: (i) speciation of selenium (especially selenoproteins) in cancer and neurodegenerative disease patients; (ii) supplementation of selenium in humans using functional foods and nutraceuticals; (iii) the link between selenium and selenoproteins expression and the gut microbiota and (iv) analytical methods and pitfalls for the absolute quantification of selenoproteins and selenometabolites.
dc.description.sponsorshipThis work was supported by the project PG2018-096608-B-C21 from the Spanish Ministry of Science, Innovation and Universities (MINECO), Project UHU-1256905 from the Regional Ministry of Economy, Knowledge, Business and University (Andalusian Government, Spain) and Project from The Ramón Areces Foundation. Finally, authors are grateful to FEDER (European Community) for financial support, Grant UNHU13-1E-1611.
dc.publisherTaylor and Francis
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherNeurodegenerative diseases
dc.titleInsights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota – current analytical methodologieses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Spanish Ministry of Science, Innovation and Universities (MINECO) [PG2018-096608-B-C21]

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