Show simple item record

dc.contributor.authorRodríguez Moro, Gema 
dc.contributor.authorAbril, Nieves
dc.contributor.authorJara Biedma, Rocío 
dc.contributor.authorRamírez Acosta, Sara
dc.contributor.authorGómez Ariza, José Luis 
dc.contributor.authorGarcía Barrera, Tamara
dc.identifier.citationRodríguez-Moro, G., Abril, N., Jara-Biedma, R., Ramírez-Acosta, S., Gómez-Ariza, J. L., & García-Barrera, T. (2019). Metabolic Impairments Caused by a “Chemical Cocktail” of DDE and Selenium in Mice Using Direct Infusion Triple Quadrupole Time-of-Flight and Gas Chromatography–Mass Spectrometry. Chemical Research in Toxicology, 32(10), 1940–1954.
dc.identifier.issn1520-5010 (electrónico)
dc.description.abstractAmong organic contaminants, pesticides are one of the most important groups of chemicals due to their persistent character and toxicity. However, the biological systems are exposed to a complex environment in which the contaminants can interact in a synergistic/antagonistic fashion, and for this reason, the study of “chemical cocktails” is of great interest to fully understand the final biological effect. In this way, selenium is known for its antagonistic action against several toxicants. In this paper, metabolic impairments caused by the joint exposure of p,p′-dichloro diphenyl trichloroethane (DDE) and selenium (Se) have been issued for the first time. A metabolomic workflow was applied to mice fed DDE and DDE with Se diet, on the basis of the complementary use of two organic mass spectrometric techniques, combining direct infusion mass spectrometry (DI-ESI-QqQ-TOF MS) and gas chromatography–mass spectrometry (GC–MS). The results show a good classification between the studied groups caused by about 70 altered metabolites in the liver, kidney, or brain, including the pathways of energy metabolism, degradation of phospholipidic membrane, β-oxidation, and oxidative stress, which confirm the potential of combined metabolomic platforms in environmental studies.
dc.description.sponsorshipThis work has been supported by projects CTM2015-67902-C2-1-P and PG2018-096608 B-C21 from the Spanish Ministry of Economy and Competitiveness and P12-FQM-0442 and B10-1657 from the Regional Ministry of Economy, Innovation, Science and Employment (Andalusian Government, Spain). G.R.-M. thanks the Spanish Ministry of Economy and Competitiveness for a PhD scholarship (BES-2013-064501). S.R.-A. thanks the Spanish Ministry of Economy and Competitiveness for a PhD scholarship (BES-2016-076364). Finally, the authors are grateful to FEDER (European Community) for financial support, Grant Nos. UNHU13-1E-1611 and UNHU15-CE-3140.
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titleMetabolic impairments caused by a “chemical cocktail” of DDE and selenium in mice using direct infusion triple quadrupole time of flight and gas chromatography mass spectrometryes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Spanish Ministry of Economy and Competitiveness [CTM2015-67902-C2-1-P, PG2018-096608 B-C2, BES-2013-064501, BES-2016-076364]

Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España

Copyright © 2008-2010. ARIAS MONTANO. Repositorio Institucional de la Universidad de Huelva
Contact Us | Send Feedback |