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dc.contributor.authorBlázquez Carmona, Pablo
dc.contributor.authorMora Macías, Juan
dc.contributor.authorMorgaz, Juan
dc.contributor.authorReina Romo, Esther
dc.identifier.citationBlázquez Carmona, P., Mora Macías, J., Morgaz, J. ... Reina Romo, E. (2020). Mechanobiology of Bone Consolidation During Distraction Osteogenesis: Bone Lengthening Vs. Bone Transport. Annals of Biomedical Engineering . DOI:
dc.description.abstractBone lengthening and bone transport are regeneration processes that commonly rely on distraction osteogenesis, a widely accepted surgical procedure to deal with numerous bony pathologies. Despite the extensive study in the literature of the influence of biomechanical factors, a lack of knowledge about their mechanobiological differences prevents a clinical particularization. Bone lengthening treatments were performed on sheep metatarsus by reproducing the surgical and biomechanical protocol of previous bone transport experiments. Several in vivo monitoring techniques were employed to build an exhaustive comparison: gait analysis, radiographic and CT assessment, force measures through the fixation, or mechanical characterization of the new tissue. A significant initial loss of the bearing capacity, quantified by the ground reaction forces and the limb contact time with the ground, is suffered by the bone lengthening specimens. The potential effects of this anomaly on the musculoskeletal force distribution and the evolution of the bone callus elastic modulus over time are also analyzed. Imaging techniques also seem to reveal lower bone volume in the bone lengthening callus than in the bone transport one, but an equivalent mineralization rate. The simultaneous quantification of biological and mechanical parameters provides valuable information for the daily clinical routine and numerical tools development.es_ES
dc.relation.isversionofPublisher’s versión
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherDistraction osteogenesises_ES
dc.subject.otherGait analysises_ES
dc.subject.otherIn vivoes_ES
dc.subject.otherStiffness monitoringes_ES
dc.subject.otherBone consolidationes_ES
dc.subject.otherBone consolidationes_ES
dc.subject.otherCallus volumees_ES
dc.titleMechanobiology of Bone Consolidation During Distraction Osteogenesis: Bone Lengthening Vs. Bone Transportes_ES

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