Show simple item record

dc.contributor.authorTriebner, Kai
dc.contributor.authorJohannessen, Ane
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorSánchez Ramos, José Luis
dc.identifier.citationTriebner, K., Johannessen, A., Svanes, C. ... Sánchez Ramos, J. L. (2020). Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels. PLOS ONE, 15(6), e0235478. DOI:
dc.description.abstractObjective Most women live to experience menopause and will spend 4–8 years transitioning from fer- tile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined categorically as pre-, peri- and postmenopause; categories that are sometimes supported by measurements of sex hormones in blood samples. We aimed to develop and validate a new tool, a reproductive ageing score (RAS), that could give a sim- ple and yet precise description of the status of reproductive ageing, without hormone mea- surements, to be used by health professionals and researchers. Methods Questionnaire data on age, menstrual regularity and menstrual frequency was provided by the large multicentre population-based RHINE cohort. A continuous reproductive ageing score was developed from these variables, using techniques of fuzzy mathematics, to gen- erate a decimal number ranging from 0.00 (nonmenopausal) to 1.00 (postmenopausal). The RAS was then validated with sex hormone measurements (follicle stimulating hormone and 17β-estradiol) and interview-data provided by the large population-based ECRHS cohort, using receiver-operating characteristics (ROC). Results The RAS, developed from questionnaire data of the RHINE cohort, defined with high preci- sion and accuracy the menopausal status as confirmed by interview and hormone data in the ECRHS cohort. The area under the ROC curve was 0.91 (95% Confidence interval (CI): 0.90–0.93) to distinguish nonmenopausal women from peri- and postmenopausal women, and 0.85 (95% CI: 0.83–0.88) to distinguish postmenopausal women from nonmenopausal and perimenopausal women. Conclusions The RAS provides a useful and valid tool for describing the status of reproductive ageing accurately, on a continuous scale from 0.00 to 1.00, based on simple questions and without requiring blood sampling. The score allows for a more precise differentiation than the con- ventional categorisation in pre-, peri- and postmenopause. This is useful for epidemiological research and clinical trials.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher’s versión
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherReproductive ageinges_ES
dc.subject.otherHormone levelses_ES
dc.titleDescribing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levelses_ES

Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España

Copyright © 2008-2010. ARIAS MONTANO. Repositorio Institucional de la Universidad de Huelva
Contact Us | Send Feedback |