Measures to prevent and contain the COVID-19 health crisis include population confinement,
with the consequent isolation and interruption of their usual activities. The aim of the study is to analyse
psychological distress during the COVID-19 pandemic. For this, a cross-sectional observational study with
a sample of 4180 people over the age of 18 during quarantine was developed. Variables considered were
sociodemographic variables, physical symptoms, health conditions, COVID-19 contact history and
psychological adjustment. The data were collected through a self-developed questionnaire and the General
Health Questionnaire (GHQ-12). Bivariate analyses were performed, including Chi-Squared test and
Student’s T-test. Predictive ability was calculated through logistic regression. Results obtained showed a
high level of psychological distress (72.0%), with a higher percentage in women and people of lower
middle age. Statistically significant differences were found in the variable working situation (χ² = 63.139,
p ≤ 0.001, V = 0.123) and living with children under the age of 16 (χ² = 7.393, p = 0.007, V = 0.042). The
predictive variables with the highest weight were sex (OR = 1.952, 95% IC = (1.667, 2.286)), presence of
symptoms (OR = 1.130, 95% CI = (1.074, 1.190)), and having had close contact with an individual with
confirmed COVID-19 (OR = 1.241, 95% CI = (1.026, 1.500)). These results could enrich prevention
interventions in public health and, in particular, in mental health in similar pandemic situations.