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dc.contributor.authorPérez Sousa, Miguel Ángel
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorSáez de Asteasu, Mikel L.
dc.contributor.authorCano Gutiérrez, Carlos A.
dc.contributor.authorRincón Pabón, David
dc.contributor.authorIzquierdo, Mikel
dc.identifier.citationRamírez Vélez, R., Pérez Sousa, M. Á., García Hermoso, A. ... Zambom Ferraresi, F. (2020). Relative Handgrip Strength Diminishes the Negative Effects of Excess Adiposity on Dependence in Older Adults: A Moderation Analysis. Journal of Clinical Medicine, 9(4), 1152. DOI:
dc.description.abstractThe adverse e ects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect of excess adiposity on dependence, and to provide the threshold of relative HGS from which the adverse e ect could be improved or worsened. A total of 4169 participants (69.3 +- 7.0 years old) from 244 municipalities were selected following a multistage area probability sampling design. Measurements included anthropometric/adiposity markers (weight, height, body mass index, waist circumference, and waist-to-height ratio (WHtR)), HGS, sarcopenia “proxy” (calf circumference), and ADL (Barthel Index scale). Moderation analyses were performed to identify associations between the independent variable (WHtR) and outcomes (dependence), as well as to determine whether relative HGS moderates the relationship between excess adiposity and dependence. The present study demonstrated that (i) the adverse e ect of having a higher WHtR level on dependence in ADL was moderated by relative HGS, and (ii) two moderation thresholds of relative HGS were estimated: 0.35, below which the adverse effect of WHtR levels on dependency is aggravated, and 0.62, above which the adverse effect of fat on dependency could be improved. Because muscular strength represents a critically important and modifiable predictor of ADL, and the increase in adiposity is inherent in aging, our results underscore the importance of an optimal level of relative HGS in the older adult population.es_ES
dc.relation.isversionofPublisher’s versión
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherFat masses_ES
dc.subject.otherMuscle strengthes_ES
dc.subject.otherPhysical functiones_ES
dc.subject.otherFunctional dependencees_ES
dc.titleRelative Handgrip Strength Diminishes the Negative Effects of Excess Adiposity on Dependence in Older Adults: A Moderation Analysises_ES

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