Ruthenium-Catalyzed Heck-Type Alkenylation of Alkyl Bromides

Muñoz Molina, José María; Pérez Romero, Pedro José

doi:10.1021/acs.joc.9b00898

Author

Muñoz Molina, José María ; Pérez Romero, Pedro José
Publication Date

2019-05-27
Publisher

American Chemical Society
Citation

Muñoz Molina, J.M., Pérez Romero, P.J.: "Ruthenium-Catalyzed Heck-Type Alkenylation of Alkyl Bromides". Journal of Organic Chemistry. Vol. 84, 12, (2019). https://doi.org/10.1021/acs.joc.9b00898
Abstract

The complex [Cp*RuCl(PPh3)2] displays a high catalytic activity for the Heck-type alkenylation of alkyl bromides, in the first example using this metal under thermal conditions. The coupling reaction proceeds efficiently with a variety of functionalized tertiary, secondary, and primary alkyl bromides. The presence of Hünig’s base has been revealed crucial for this transformation. Preliminary mechanistic studies support the participation of alkyl radicals in the reaction.
URI

http://hdl.handle.net/10272/16747
Project

info:eu-repo/grantAgreement/Spanish Ministry of Economy & Competitiveness [CTQ2017-82893-C2-1-R]

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Ruthenium-Catalyzed Heck-Type Alkenylation of Alkyl Bromides

Author

Muñoz Molina, José María UHU Authority

; Pérez Romero, Pedro José UHU Authority

Publication Date

2019-05-27

Publisher

American Chemical Society

Citation

Muñoz Molina, J.M., Pérez Romero, P.J.: "Ruthenium-Catalyzed Heck-Type Alkenylation of Alkyl Bromides". Journal of Organic Chemistry. Vol. 84, 12, (2019). https://doi.org/10.1021/acs.joc.9b00898

Abstract

The complex [Cp*RuCl(PPh3)2] displays a high catalytic activity for the Heck-type alkenylation of alkyl bromides, in the first example using this metal under thermal conditions. The coupling reaction proceeds efficiently with a variety of functionalized tertiary, secondary, and primary alkyl bromides. The presence of Hünig’s base has been revealed crucial for this transformation. Preliminary mechanistic studies support the participation of alkyl radicals in the reaction.

URI

http://hdl.handle.net/10272/16747

Project

info:eu-repo/grantAgreement/Spanish Ministry of Economy & Competitiveness [CTQ2017-82893-C2-1-R]

Fichero	Tamaño	Formato	Ver	Description
Ruthenium-Catalyzed.pdf	1.113Mb	PDF	View/Open	versión post-print

Fichero	Tamaño	Formato	Ver	Description
Ruthenium-Catalyzed.pdf	1.113Mb	PDF	View/Open	versión post-print