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dc.contributor.authorHuerta, José M.
dc.contributor.authorRamos Lora, Manuel
dc.contributor.authorAragonés, Nuria
dc.identifier.citationHuerta, J. M., Ramos Lora, M., Aragonés, N... [et al.] (2017). Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study. PLOS ONE, 12(7), e0179731.
dc.description.abstractBackground Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. Methods 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse). Results Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95`)Cl: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non -sedentary participants. Conclusions Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.es_ES
dc.description.sponsorshipThe study was partially funded by the 'Action Transversal del Cancer', approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundacion Marques de Valdecilla (API 10/09), the Junta de Castilla y Leon (LE22A10-2), the Consejeria de Salud of the Junta de Andalucia (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional Government of the Basque Country, the Consejeria de Sanidad de la Region de Murcia, the European Commission grants FOOD-CT-2006-036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the Catalan Government DURSI grant 2014SGR647, the Fundacion Caja de Ahorros de Asturias and by the University of Oviedo.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titlePhysical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control studyes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265]es_ES

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