Thesis Collection
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Browsing by Author "Vitorica, Javier"
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Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease
González Domínguez, Raúl
; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential for the study of pathological mechanisms and the development of new therapies and biomarkers for ... -
Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological and cognitive deficits observed in human Alzheimer's disease. In this study, serum samples from APP/PS1 ... -
Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Royal Society of Chemistry, 2015)
There is growing evidence that Alzheimer's disease may be a widespread systemic disorder, so peripheral organs could be affected by pathological mechanisms occurring in this neurodegenerative disease. For this reason, a ... -
Metabolomic research on the role of interleukin-4 in Alzheimer’s disease
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Springer Verlag, 2015)
Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral system. Thus, modulation of inflammation in animal models of this neurodegenerative disorder may be ... -
Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery of potential markers for diagnosis and disease monitoring. In this study, we investigated regional ...
