Thesis Collection
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Browsing by Author "Lechuga Sancho, Alfonso María"
Now showing items 1-7 of 7
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Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance
González Domínguez, Álvaro; Millán Martínez, María; Domínguez Riscart, Jesús; Mateos, Rosa María; Lechuga Sancho, Alfonso María; González Domínguez, Raúl
(MDPI, 2022)
Metals are redox-active substances that participate in central biological processes and may be involved in a multitude of pathogenic events. However, considering the inconsistencies reported in the literature, further ... -
Exploring the association between circulating trace elements, metabolic risk factors, and the adherence to a Mediterranean diet among children and adolescents with obesity
González Domínguez, Álvaro; Domínguez Riscart, Jesús; Millán Martínez, María; Lechuga Sancho, Alfonso María; González Domínguez, Raúl (Frontiers Media, 2023-01)
Diet is one of the most important modifiable lifestyle factors for preventing and treating obesity. In this respect, the Mediterranean diet (MD) has proven to be a rich source of a myriad of micronutrients with positive ... -
Iron Metabolism in Obesity and Metabolic Syndrome
González Domínguez, Álvaro; González Domínguez, Raúl; Visiedo García, Francisco; Lechuga Sancho, Alfonso María (MDPI, 2020-08)
Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence ... -
Mechanistic Insights into Alzheimer’s Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways
González Domínguez, Raúl; González Domínguez, Álvaro; Sayago Gómez, Ana; González Sanz, Juan Diego; Lechuga Sancho, Alfonso María; Fernández Recamales, María Ángeles (BIOMEDICINES, 2021)
Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer’s disease. ... -
Metal Homeostasis and Exposure in Distinct Phenotypic Subtypes of Insulin Resistance among Children with Obesity
González Domínguez, Álvaro; Millán Martínez, María; Domínguez Riscart, Jesús; Lechuga Sancho, Alfonso María; González Domínguez, Raúl (MDPI, 2023-05)
Background: Trace elements and heavy metals have proven pivotal roles in childhood obesity and insulin resistance. However, growing evidence suggests that insulin resistance could encompass distinct phenotypic subtypes. ... -
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones
González Domínguez, Álvaro; Domínguez Riscart, Jesús; Millán Martínez, María; Lechuga Sancho, Alfonso María; González Domínguez, Raúl (Wiley, 2023)
Although growing evidence points to a pivotal role of perturbed metal homeostasis in childhood obesity, sexual dimorphisms in this association have rarely been investigated. In this study, we applied multi-elemental ... -
Trace elements as potential modulators of puberty-induced amelioration of oxidative stress and inflammation in childhood obesity
González Domínguez, Álvaro; Domínguez Riscart, Jesús; Millán Martínez, María; Mateos Bernal, Rosa María; Lechuga Sancho, Alfonso María; González Domínguez, Raúl (Wiley, 2023)
Although puberty is known to influence obesity progression, the molecular mechanisms underlying the role of sexual maturation in obesity-related complications remains largely unexplored. Here, we delve into the impact ...
