Thesis Collection
Last Deposit
Browsing by Author "Gómez Ariza, José Luis"
Now showing items 1-20 of 65
-
A combination of metallomics and metabolomics studies to evaluate the effects of metal interactions in mammals. Application to Mus musculus mice under arsenic/cadmium exposure
García Sevillano, Miguel Ángel
; García Barrera, Tamara; Navarro Roldán, Francisco Juan; Montero Lobato, Zaida; Gómez Ariza, José Luis (Elsevier, 2014)
Arsenic and cadmium are toxic metals of environmental significance with harmful effects on man. To study the toxicological and biochemical effects of arsenic/cadmium in mammals a combined metallomic and metabolomic approach ... -
A multiple hollow fibre liquid-phase microextraction method for the determination of halogenated solvent residues in olive oil
Manso Sayago, José Manuel; García Barrera, Tamara; Gómez Ariza, José Luis (Springer Verlag, 2014)
The present paper describes a method based on the extraction of analytes by multiple hollow fibre liquid-phase microextraction and detection by ion-trap mass spectrometry and electron capture detectors after gas chromatographic ... -
Absolute quantification of superoxide dismutase in cytosol and mitochondria of mice hepatic cells exposed to mercury by a novel metallomic approach
García Sevillano, Miguel Ángel; García Barrera, Tamara; Navarro, Francisco; Gómez Ariza, José Luis (Elsevier Masson, 2014)
In the last years, the development of new methods for analyzing accurate and precise individual metalloproteins is of increasing importance, since numerous metalloproteins are excellent biomarkers of oxidative stress and ... -
Antagonistic Interaction of Selenium and Cadmium in Human Hepatic Cells Through Selenoproteins
Ramírez Acosta, Sara; Uhlírová, R.; Navarro Roldán, Francisco Juan; Gómez Ariza, José Luis; García Barrera, Tamara (Frontiers Media, 2022)
Cadmium (Cd) is a highly toxic heavy metal for humans and animals, which is associated with acute hepatotoxicity. Selenium (Se) confers protection against Cd-induced toxicity in cells, diminishing the levels of ROS and ... -
Antagonistic interaction of selenomethionine enantiomers on methylmercury toxicity in the microalgae Chlorella sorokiniana
Moreno Roldán, Fernando; García Barrera, Tamara; Gómez Jacinto, Verónica; Gómez Ariza, José Luis; Garbayo Nores, Inés; Vílchez Lobato, Carlos (Royal Society of Chemistry, 2014)
The protective effect of selenium against mercury toxicity is well known especially between selenomethionine and methylmercury and it has been studied in several living organisms, however information is lacking about the ... -
Application of a novel metabolomic approach based on atmospheric pressure photoionization mass spectrometry using flow injection analysis for the study of Alzheimer׳s disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2015)
The use of atmospheric pressure photoionization is not widespread in metabolomics, despite its considerable potential for the simultaneous analysis of compounds with diverse polarities. This work considers the development ... -
Application of hollow fiber liquid phase microextraction for simultaneous determination of regulated and emerging iodinated trihalomethanes in drinking water
Domínguez Tello, Antonio; Arias Borrego, Ana; García Barrera, Tamara; Gómez Ariza, José Luis (Journal of Chromatography A, 2015)
Trihalomethanes (THMs) are regulated disinfection by-products (DBPs) most commonly analyzed in quality control water supply due to their harmful effects on health. However, few data exist about the content of emerging ... -
Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential for the study of pathological mechanisms and the development of new therapies and biomarkers for ... -
Arsenic metabolites in human serum and urine after seafood (Anemonia sulcata) consumption and bioaccessibility assessment using liquid chromatography coupled to inorganic and organic mass spectrometry
Contreras Acuña, Manuel; García Barrera, Tamara; García Sevillano, Miguel Ángel; Gómez Ariza, José Luis (Elsevier, 2014)
The present paper reports for the first time the bioaccessibility of arsenic species in Anemonia sulcata and its metabolization in the human body after the ingestion of this seafood, a delicacy highly appreciated in the ... -
Biodegradation of a Complex Phenolic Industrial Stream by Bacterial Strains Isolated from Industrial Wastewaters
Bartolomé, Alejandra; Rodríguez Moro, Gema; Fuentes Cordero, Juan Luis; Lopes, Mariana; Frontela, Juana; Lázaro, Jesús; Cuaresma Franco, María; Gómez Ariza, José Luis; García Barrera, Tamara; Vílchez Lobato, Carlos (MDPI, 2021)
Molecular and metabolomic tools were used to design and understand the biodegradation of phenolic compounds in real industrial streams. Bacterial species were isolated from an industrial wastewater treatment plant of a ... -
Biological interactions between mercury and selenium in distribution and detoxification processes in mice under controlled exposure. Effects on selenoprotein
García Sevillano, Miguel Ángel; Rodríguez Moro, Gema; García Barrera, Tamara; Navarro, Francisco; Gómez Ariza, José Luis (Elsevier, 2015)
Antagonistic interactions between mercury (Hg) and selenium (Se), were evaluated in mouse (Mus musculus), as a mammalian model, in a series of controlled exposure experiments. The beneficial effect of Se against Hg toxicity ... -
Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species
García Barrera, Tamara; Gómez Ariza, José Luis; González Fernández, Macarena; Moreno Roldán, Fernando; García Sevillano, Miguel Ángel; Gómez Jacinto, Verónica (Springer Verlag, 2012)
The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number ... -
Cadmium toxicity in Mus musculus mice based on metallomic and metabolomic approaches. Antagonistic interaction between Se and Cd in the bloodstream
García Sevillano, Miguel Ángel; García Barrera, Tamara; Gómez Ariza, José Luis; Navarro, Francisco (Royal Society of Chemistry, 2014)
Cadmium (Cd) is an important inorganic toxicant in the environment which impacts on human health. A metallomic approach based on size-exclusion chromatography (SEC) coupled to inductively coupled plasma-mass spectrometry ... -
Characterization of the metal profile in serum during the progression of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Oxford University Press, 2014)
Metal dyshomeostasis is closely related to Alzheimer's disease, so the characterization of the metal profiles in these patients is of special interest for studying associated neurodegenerative processes and to discover ... -
Combinación de metodologías ómicas y mea-ómicas para estudiar el efecto de la suplementación de selenio y su interacción con la microbiota intestinal
(Universidad de Huelva, 2022)El selenio (Se) es un elemento esencial para la salud humana con importantes funciones para el organismo. Está presente de forma natural en el medio ambiente tanto en formas orgánicas como inorgánicas. En el organismo, se ... -
Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2014)
Alzheimer's disease is closely related to abnormal metabolism of phospholipids from neural membranes, so that the study of their dyshomeostasis could be of great interest for the discovery of potential biomarkers for ... -
Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological and cognitive deficits observed in human Alzheimer's disease. In this study, serum samples from APP/PS1 ... -
Desarrollo de metodología ómicas para el estudio y diagnóstico precoz del cáncer de pulmón
Callejón Leblic, María Belén (Universidad de Huelva, 2019)
El cáncer de pulmón (CP) constituye una de las muertes más comunes por neoplasia en el mundo provocando más de 1.300.000 muertes al año. La supervivencia a 5 años comprende un 65% cuando la enfermedad se diagnostica en ... -
Desarrollo de métodos analíticos metabolómicos y metalómicos para el estudio de la enfermedad de Alzheimer : diseño de nuevos biomarcadores químicos de diagnosis
González Domínguez, Raúl (Universidad de Huelva, 2015)
La enfermedad de Alzheimer (EA) es el trastorno neurodegenerativo más común entre la población de edad avanzada, el cual se caracteriza por un inicio insidioso y un declive progresivo de las funciones cognitivas, En la ... -
Desarrollo de métodos basados en el uso de membranas para la determinación de microcontaminantes orgánicos en alimentos, medio ambiente y fluidos biológicos
Manso Sayago, José Manuel (Universidad de Huelva, 2013)
Los alimentos constituyen una importante interfase entre el medio ambiente y la salud, pudiendo producirse efectos en la salud humana derivados de la presencia de sustancias tóxicas originadas por la contaminación del medio ...
