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Browsing by Author "García Sevillano, Miguel Ángel"
Now showing items 1-11 of 11
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A combination of metallomics and metabolomics studies to evaluate the effects of metal interactions in mammals. Application to Mus musculus mice under arsenic/cadmium exposure
García Sevillano, Miguel Ángel
; García Barrera, Tamara; Navarro Roldán, Francisco Juan; Montero Lobato, Zaida; Gómez Ariza, José Luis (Elsevier, 2014)
Arsenic and cadmium are toxic metals of environmental significance with harmful effects on man. To study the toxicological and biochemical effects of arsenic/cadmium in mammals a combined metallomic and metabolomic approach ... -
Absolute quantification of superoxide dismutase in cytosol and mitochondria of mice hepatic cells exposed to mercury by a novel metallomic approach
García Sevillano, Miguel Ángel; García Barrera, Tamara; Navarro, Francisco; Gómez Ariza, José Luis (Elsevier Masson, 2014)
In the last years, the development of new methods for analyzing accurate and precise individual metalloproteins is of increasing importance, since numerous metalloproteins are excellent biomarkers of oxidative stress and ... -
Arsenic metabolites in human serum and urine after seafood (Anemonia sulcata) consumption and bioaccessibility assessment using liquid chromatography coupled to inorganic and organic mass spectrometry
Contreras Acuña, Manuel; García Barrera, Tamara; García Sevillano, Miguel Ángel; Gómez Ariza, José Luis (Elsevier, 2014)
The present paper reports for the first time the bioaccessibility of arsenic species in Anemonia sulcata and its metabolization in the human body after the ingestion of this seafood, a delicacy highly appreciated in the ... -
Biological interactions between mercury and selenium in distribution and detoxification processes in mice under controlled exposure. Effects on selenoprotein
García Sevillano, Miguel Ángel; Rodríguez Moro, Gema; García Barrera, Tamara; Navarro, Francisco; Gómez Ariza, José Luis (Elsevier, 2015)
Antagonistic interactions between mercury (Hg) and selenium (Se), were evaluated in mouse (Mus musculus), as a mammalian model, in a series of controlled exposure experiments. The beneficial effect of Se against Hg toxicity ... -
Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species
García Barrera, Tamara; Gómez Ariza, José Luis; González Fernández, Macarena; Moreno Roldán, Fernando; García Sevillano, Miguel Ángel; Gómez Jacinto, Verónica (Springer Verlag, 2012)
The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number ... -
Cadmium toxicity in Mus musculus mice based on metallomic and metabolomic approaches. Antagonistic interaction between Se and Cd in the bloodstream
García Sevillano, Miguel Ángel; García Barrera, Tamara; Gómez Ariza, José Luis; Navarro, Francisco (Royal Society of Chemistry, 2014)
Cadmium (Cd) is an important inorganic toxicant in the environment which impacts on human health. A metallomic approach based on size-exclusion chromatography (SEC) coupled to inductively coupled plasma-mass spectrometry ... -
Estudio metalómico/metabolómico comparativo del ratón de laboratorio Mus musculus y del ratón de vida libre Mus spretus para evaluar el estrés ambiental de ecosistemas terrestres
García Sevillano, Miguel Ángel (Universidad de Huelva, 2016)
La diagnosis del estrés ambiental, precisa la combinación de ensayos químicos de los contaminantes en el medio, con el conocimiento de la respuesta biológica a dichos contaminantes. Esta respuesta puede evaluarse mediante ... -
Functional genomics and metabolomics reveal the toxicological effects of cadmium in Mus musculus mice
García Sevillano, Miguel Ángel; Abril, Nieves; Fernández Cisnal, R.; García Barrera, Tamara; Pueyo, Carmen; López Barea, Juan; Gómez Ariza, José Luis (Springer Verlag, 2015)
Cadmium (Cd) is an environmental pollutant that accumulates in the organisms causing serious health problems. Over the past decades, omics studies have been conducted trying to elucidate changes in the genome, the transcriptome ... -
Microalgae as a safe food source for animals: nutritional characteristics of the acidophilic microalga Coccomyxa onubensis
Navarro Roldán, Francisco Juan; Forján Lozano, Eduardo; Vázquez, María; Montero, Zaida; Bermejo, Elisabeth; Castaño López, Miguel Ángel; Toimil, Alberto; Chagüaceda, Enrique; García Sevillano, Miguel Ángel (Elsevier, 2016)
Background: Edible microalgae are marine or fresh water mesophilic species. Although the harvesting of microalgae offers an abundance of opportunities to the food and pharmaceutical industries, the possibility to use ... -
Omics technologies and their applications to evaluate metal toxicity in mice M. spretus as a bioindicator
García Sevillano, Miguel Ángel; García Barrera, Tamara; Abril, Nieves; Pueyo, Carmen; López Barea, Juan; Gómez Ariza, José Luis (Elsevier, 2014)
Metals are important components of living organisms since many biological functions critically depend on their interaction with some meta l in the cell. However, human activities have increased toxic metal levels in the ... -
Simultaneous speciation of selenoproteins and selenometabolites in plasma and serum by dual size exclusion-affinity chromatography with online isotope dilution inductively coupled plasma mass spectrometry
García Sevillano, Miguel Ángel; García Barrera, Tamara; Gómez Ariza, José Luis (Springer Verlag, 2014)
A method for the simultaneous speciation of selenoproteins and selenometabolites in mouse plasma has been developed based on in series two-dimensional size exclusion and affinity high-performance liquid chromatography ...
