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Browsing by Author "González Domínguez, Raúl"
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An Overview on the Application of Chemometrics Tools in Food Authenticity and Traceability
González Domínguez, Raúl
; Sayago Gómez, Ana; Fernández Recamales, María Ángeles (MDPI, 2022-12)
The use of advanced chemometrics tools in food authenticity research is crucial for managing the huge amount of data that is generated by applying state-of-the-art analytical methods such as chromatographic, spectroscopic, ... -
Application of a novel metabolomic approach based on atmospheric pressure photoionization mass spectrometry using flow injection analysis for the study of Alzheimer׳s disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2015)
The use of atmospheric pressure photoionization is not widespread in metabolomics, despite its considerable potential for the simultaneous analysis of compounds with diverse polarities. This work considers the development ... -
Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential for the study of pathological mechanisms and the development of new therapies and biomarkers for ... -
Assessment of Virgin Olive Oil Adulteration by a Rapid Luminescent Method
González Domínguez, Raúl; Sayago Gómez, Ana; Morales, María Teresa; Fernández Recamales, María Ángeles (MDPI, 2019-07)
The adulteration of virgin olive oil with hazelnut oil is a common fraud in the food industry, which makes mandatory the development of accurate methods to guarantee the authenticity and traceability of virgin olive oil. ... -
Characterization of the metal profile in serum during the progression of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Oxford University Press, 2014)
Metal dyshomeostasis is closely related to Alzheimer's disease, so the characterization of the metal profiles in these patients is of special interest for studying associated neurodegenerative processes and to discover ... -
Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2014)
Alzheimer's disease is closely related to abnormal metabolism of phospholipids from neural membranes, so that the study of their dyshomeostasis could be of great interest for the discovery of potential biomarkers for ... -
Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
González Domínguez, Raúl; García Barrera, Tamara; Vitorica, Javier; Gómez Ariza, José Luis (Elsevier, 2015)
The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological and cognitive deficits observed in human Alzheimer's disease. In this study, serum samples from APP/PS1 ... -
Desarrollo de métodos analíticos metabolómicos y metalómicos para el estudio de la enfermedad de Alzheimer : diseño de nuevos biomarcadores químicos de diagnosis
González Domínguez, Raúl (Universidad de Huelva, 2015)
La enfermedad de Alzheimer (EA) es el trastorno neurodegenerativo más común entre la población de edad avanzada, el cual se caracteriza por un inicio insidioso y un declive progresivo de las funciones cognitivas, En la ... -
Development and characterization of new fermented beverages of low alcoholic graduation from strawberry
Fernández Recamales, María Ángeles; Sayago Gómez, Ana; González Domínguez, Raúl; López Carbón, Verónica; Akhatou, Ikram; Beltrán Lucena, Rafael (MDPI, 2016)
Nowadays, the oenological market tends to the diversification through the development of new original and enriched products. Thus, the study here proposed pretends the elaboration and characterization of new "wine-type" ... -
Development of a metabolomic approach based on urine samples and direct infusion mass spectrometry
González Domínguez, Raúl; Castilla Quintero, Rocío; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2014)
The analysis of urine by direct infusion mass spectrometry suffers from ion suppression due to its high salt content and inter-sample variability caused by the differences in urine volume between persons. Thus, urine ... -
Evolution of Physicochemical Parameters during the Thermal-Based Production of Água-mel, a Traditional Portuguese Honey-Related Food Product
Cavaco, Teresa; Figueira, Ana Cristina; González Domínguez, Raúl; Sayago Gómez, Ana; Fernández Recamales, María Ángeles (MDPI, 2022)
The purpose of this work was to investigate the physicochemical changes occurring during the thermal-based production of água-mel, a traditional Portuguese honey-related food product. The refractive index, color parameters ... -
Fatty Acid Profiling for the Authentication of Iberian Hams According to the Feeding Regime
González Domínguez, Raúl; Sayago Gómez, Ana; Fernández Recamales, María Ángeles (MDPI, 2020-02)
The quality and sensory characteristics of Iberian ham are closely related to the pig feeding regime. These are mainly due to the inclusion or not of acorns into the diet, which significantly increases the content of ... -
Hollow-Fiber Liquid-Phase Micro-Extraction Method for the Simultaneous Derivatization, Extraction, and Pre-concentration of Organotin Compounds from Packed Fruit Juices
González Domínguez, Raúl; Sayago Gómez, Ana; Santos-Martín, María; Fernández Recamales, María Ángeles (Springer, 2022)
Organotin compounds are widely employed as pesticides and fungicides in agriculture and as stabilizers for the industrial manufacture of polyvinyl chloride and other polymers. Accordingly, these endocrine disruptors can ... -
Homeostasis of metals in the progression of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Springer Verlag, 2014)
In order to study the involvement of metals in the progression of Alzheimer's disease, serum samples from patients with Alzheimer and mild cognitive impairment were investigated. For this purpose, metal content was analyzed ... -
Impact of dietary mercury intake during pregnancy on the health of neonates and children: a systematic review
Saavedra, Steven; Fernández Recamales, María Ángeles; Sayago Gómez, Ana; Cervera Barajas, Antonio; González Domínguez, Raúl; González Sanz, Juan Diego (Oxford University Press, 2021)
Context Growing evidence suggests that prenatal exposure to methyl mercury through the maternal diet could have great influence on the neurological and physical development of neonates and young children. Objective The ... -
Iron Metabolism in Obesity and Metabolic Syndrome
González Domínguez, Álvaro; González Domínguez, Raúl; Visiedo García, Francisco; Lechuga Sancho, Alfonso María (MDPI, 2020-08)
Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence ... -
Mechanistic Insights into Alzheimer’s Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways
González Domínguez, Raúl; González Domínguez, Álvaro; Sayago Gómez, Ana; González Sanz, Juan Diego; Lechuga Sancho, Alfonso María; Fernández Recamales, María Ángeles (BIOMEDICINES, 2021)
Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer’s disease. ... -
Metabolite profiling for the identification of altered metabolic pathways in Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2015)
Gas chromatography coupled to mass spectrometry is the most frequent tool for metabolomic profiling of low molecular weight metabolites. Its suitability in health survey is beyond doubt, given that primary metabolites ...
