@article{10272/18307,
year = {2020},
month = {6},
url = {http://hdl.handle.net/10272/18307},
abstract = {Metabolomics can be significantly influenced by a range of pre-analytical factors, such
as sample collection, pre-processing, aliquoting, transport, storage and thawing. This therefore
shows the crucial need for standardizing the pre-analytical phase with the aim of minimizing the
inter-sample variability driven by these technical issues, as well as for maintaining the metabolic
integrity of biological samples to ensure that metabolomic profiles are a direct expression of the
in vivo biochemical status. This review article provides an updated literature revision of the most
important factors related to sample handling and pre-processing that may affect metabolomics results,
particularly focusing on the most commonly investigated biofluids in metabolomics, namely blood
plasma/serum and urine. Finally, we also provide some general recommendations and best practices
aimed to standardize and accurately report all these pre-analytical aspects in metabolomics research.},
publisher = {MDPI},
keywords = {Metabolomics},
keywords = {Pre-analytics},
keywords = {Blood},
keywords = {Urine},
keywords = {Collection},
keywords = {Processing},
keywords = {Storage},
title = {Recommendations and Best Practices for Standardizing the Pre-Analytical Processing of Blood and Urine Samples in Metabolomics},
doi = {10.3390/metabo10060229},
author = {González Domínguez, Raúl and González Domínguez, Álvaro and Fernández Recamales, María Ángeles},
}