@article{10272/17940,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10272/17940},
abstract = {The adverse e ects of fat mass on functional dependence might be attenuated or worsened,
depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental
effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative
handgrip strength (HGS) moderates the adverse effect of excess adiposity on dependence, and to
provide the threshold of relative HGS from which the adverse e ect could be improved or worsened.
A total of 4169 participants (69.3 +- 7.0 years old) from 244 municipalities were selected following
a multistage area probability sampling design. Measurements included anthropometric/adiposity
markers (weight, height, body mass index, waist circumference, and waist-to-height ratio (WHtR)),
HGS, sarcopenia “proxy” (calf circumference), and ADL (Barthel Index scale). Moderation analyses
were performed to identify associations between the independent variable (WHtR) and outcomes
(dependence), as well as to determine whether relative HGS moderates the relationship between
excess adiposity and dependence. The present study demonstrated that (i) the adverse e ect of having
a higher WHtR level on dependence in ADL was moderated by relative HGS, and (ii) two moderation
thresholds of relative HGS were estimated: 0.35, below which the adverse effect of WHtR levels on
dependency is aggravated, and 0.62, above which the adverse effect of fat on dependency could be
improved. Because muscular strength represents a critically important and modifiable predictor of
ADL, and the increase in adiposity is inherent in aging, our results underscore the importance of an
optimal level of relative HGS in the older adult population.},
publisher = {MDPI},
keywords = {Fat mass},
keywords = {Obesity},
keywords = {Muscle strength},
keywords = {Physical function},
keywords = {Functional dependence},
title = {Relative Handgrip Strength Diminishes the Negative Effects of Excess Adiposity on Dependence in Older Adults: A Moderation Analysis},
doi = {10.3390/jcm9041152},
author = {Pérez Sousa, Miguel Ángel and Ramírez Vélez, Robinson and García Hermoso, Antonio and Zambom Ferraresi, Fabrício and Martínez Velilla, Nicolás and Sáez de Asteasu, Mikel L. and Cano Gutiérrez, Carlos A. and Rincón Pabón, David and Izquierdo, Mikel},
}