The health effects of COVID-19 continue to raise doubts today. In some areas, such as
mental health, these doubts have scarcely been addressed. The present study analyses the effects on
psychological distress during the first phase of the pandemic in Chile. A cross-sectional descriptive
study was performed by using a questionnaire validated in Spain and adapted for Chile. Between
22 April and 16 December 2020, 3227 questionnaires were collected from the 16 regions of Chile,
using non-probabilistic snowball sampling. Bivariate analysis and binary logistic regression were
performed. The variables that could predict psychological distress during the COVID-19 pandemic in
Chile were: having a poor self-perception of health OR = 4.038, 95% CI = (2.831, 5.758); being younger
than 29 OR = 2.287, 95% CI = (1.893, 2.762); having diarrhea OR = 2.093, 95% CI = (1.414, 3.098);
having headache OR = 2.019, 95% CI = (1.662, 2.453); being a woman OR = 1.638, 95% CI = (1.363,
1.967); having muscle pain OR = 1.439, 95% CI = (1.114, 1.859); and having had casual contact with an
infected person OR = 1.410, 95% CI = (1.138, 1.747). In Chile, with a better social, economic, cultural,
and health environment compared to neighboring countries, there has been a high percentage of
psychological distress. It is time to prioritize measures to safeguard the mental health of Chileans,
especially focused on the most vulnerable population according to our results, i.e., young women
with poorer health status.