Show simple item record

dc.contributor.authorPesce, Giancarlo
dc.contributor.authorTriebner, Kai
dc.contributor.authorPlaat, Diana A. van der
dc.contributor.authorSánchez Ramos, José Luis 
dc.date.accessioned2021-06-08T07:14:13Z
dc.date.available2021-06-08T07:14:13Z
dc.date.issued2020-06
dc.identifier.citationPesce, G., Triebner, K., Plaat, D. A. ... Sanchez Ramos, J. L. (2020). Low serum DHEA-S is associated with impaired lung function in women. EClinicalMedicine, 23, 100389. DOI: https://doi.org/10.1016/j.eclinm.2020.100389es_ES
dc.identifier.issn2589-5370
dc.identifier.urihttp://hdl.handle.net/10272/19945
dc.description.abstractBackground: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999 2002 and in 2010 2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999 2002 with incidence of restrictive pattern and airflow limitation in 2010 2013 were also assessed. Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPublisher’s versión
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.otherAndrogenses_ES
dc.subject.otherSex hormoneses_ES
dc.subject.otherAirflow obstructiones_ES
dc.subject.otherCohort studieses_ES
dc.titleLow serum DHEA-S is associated with impaired lung function in womenes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.eclinm.2020.100389
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España

Copyright © 2008-2010. ARIAS MONTANO. Repositorio Institucional de la Universidad de Huelva
Contact Us | Send Feedback |