The objective of this research was to analyse the quality of life of nursing professionals and
its relationship with socio-demographic variables and the work context. A multi-centre, descriptive,
cross-sectional design was used. Questionnaires were administered to 1521 nurses working in the
Andalusian Public Health System (APHS), Spain. Professional quality of life (ProQOL v. IV) was
measured, as well as several socio-demographic and work-related variables. To this end, a descriptive
analysis and multiple exploratory analyses were conducted. The levels of compassion fatigue (CF)
and burnout (BO) were elevated. The level of compassion satisfaction (CS) was below the estimated
mean. Marital status, the healthcare setting, the area where the centre is located, and the work shift
are variables associated with CF. According to the multiple linear regression model, the predicting
factors for the occurrence of CF were being married, working in primary care, in urban areas, and
working a morning/evening/night shift. The variables related to CS were the professional’s age, sex,
marital status, the healthcare setting of the centre, the location of the centre, and the work shift.
Specifically, according to the exploratory model, the factors that predicted a reduction in CS were
working in primary care, in urban areas, and working a morning/evening/night shift. However, being
divorced increased CS. BO was influenced only by the work shift. Nursing professionals are exposed
to certain factors that may influence professional quality of life. Some of these factors are related to
the work context.