Measuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles
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Publication Date
2018 -
Publisher
Wiley -
Citation
Olmos, A., Gava, R., Noverges, B., Bellezza, D., Jacob, K., Besora, M., Caballero Bevia, A., Pérez Romero, P. J. (2018). Measuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles. Angewandte Chemie International Edition, 57(42), 13848-13852. https://doi.org/10.1002/anie.201807448 -
Abstract
We report quantitative measurements of the relative reactivities of a series of C-H bonds of gaseous or liquid CnH2n+2 alkanes (n = 1-8, 29 different C-H bonds) towards insitu generated electrophiles (copper, silver, and rhodium carbenes), with methane as the reference. This strategy surpasses the drawback of previous model reactions of alkanes with strong electrophiles suffering from C-C cleavage processes, which precluded direct comparison of the relative reactivities of alkane C-H bonds. -
Project
info:eu-repo/grantAgreement/MINECO [CTQ2014-52769-C03-01, CTQ2014-52769-C03-02, CTQ2017-82893-C2-1-R, CTQ2014-62234-EXP, CTQ2015-73693-JIN, CTQ2017-87792-R]
info:eu-repo/grantAgreement/Junta de Andalucia [P12-FQM-1765]
Fichero | Tamaño | Formato |
| Description |
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Measuring the relative reactivity.pdf | 1.008Mb | View/ | versión post-print |
Fichero | Tamaño | Formato |
| Description |
---|---|---|---|---|
Measuring the relative reactivity.pdf | 1.008Mb | View/ | versión post-print |