Enantio‐ and Diastereoselective Cyclopropanation of 1‐Alkenylboronates : Synthesis of 1‐Boryl‐2,3‐Disubstituted Cyclopropanes
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Publication Date
2018 -
Publisher
Wiley -
Citation
Carreras, J., Caballero, A., & Pérez, P. J. (2018). Enantio- and Diastereoselective Cyclopropanation of 1-Alkenylboronates: Synthesis of 1-Boryl-2,3-Disubstituted Cyclopropanes. Angewandte Chemie International Edition, 57(9), 2334-2338. https://doi.org/10.1002/anie.201710415 -
Abstract
A novel, highly enantio- and diastereoselective synthesis of 1-boryl-2,3-disubstituted cyclopropanes has been developed by means of the cyclopropanation of alkenylboronates with ethyl diazoacetate in the presence of catalytic amounts of a chiral copper(I) complex. The products can also be directly accessed from alkynes through an operationally simple, sequential hydroboration–cyclopropanation protocol. The resulting enantioenriched 1-boryl-2,3-disubstituted cyclopropanes are versatile synthetic intermediates that undergo further transformations at the carbon–boron bond. -
Project
info:eu-repo/grantAgreement/MINECO [CTQ2014-52769-C03-01-R]
info:eu-repo/grantAgreement/Junta de Andaluca [P12-FQM-1765]
Fichero | Tamaño | Formato |
| Description |
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Enantio- and Diastereoselective.pdf | 217.9Kb | View/ | versión post-print |
Fichero | Tamaño | Formato |
| Description |
---|---|---|---|---|
Enantio- and Diastereoselective.pdf | 217.9Kb | View/ | versión post-print |