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dc.contributor.authorGarcía Barrera, Tamara 
dc.contributor.authorGómez Ariza, José Luis 
dc.contributor.authorGonzález Fernández, Macarena 
dc.contributor.authorMoreno Roldán, Fernando 
dc.contributor.authorGarcía Sevillano, Miguel Ángel 
dc.contributor.authorGómez Jacinto, Verónica
dc.identifier.citationGarcía-Barrera, T., Gómez-Ariza, J. L., González-Fernández, M., Moreno, F., García-Sevillano, M. A., & Gómez-Jacinto, V. (2012). Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species. Analytical and Bioanalytical Chemistry, 403(8), 2237-2253.
dc.identifier.issn1618-2650 (electrónico)
dc.description.abstractThe fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number of them that provide very good performance. However, biological systems are exposed to a complex environment in which species of elements can interact in a synergistic/antagonistic fashion. Thus, the metabolism of trace elements cannot be considered in isolation. On the other hand, biological systems are dynamic, so it is necessary to study the trafficking of species of elements between organs, tissues or cell compartments in order to decipher the biochemical processes of the interactions in which they are involved. Although the application of liquid chromatography–inductively coupled plasma-based “metallomics” methods in combination with organic mass spectrometry can provide much-needed insight, new analytical strategies are required to really understand the role of species of elements in biological systems and the mechanisms of their interactions. In the present paper, the interactions of the most widely studied elements in this context (Se, Hg and As) are discussed, as well as other important interactions between different elements.es_ES
dc.description.sponsorshipThis work was supported by the project CTM2009-12858-C02-01 from the Spanish Ministry of Science and Education, and the projects P08-FQM-03554 and P09-FQM-4659 from the Innovation, Science and Enterprise Agency (Andalusian Government). M. Gonzalez-Fernandez thanks the Spanish Ministry of Education/Ministry of Science and Innovation (Campus of Excellence-CiA3 Program) for a postdoctoral grant. M. A. Garcia Sevillano thanks the Ministry of Education for a Ph.D. scholarship (FPU). V. Gomez-Jacinto thanks the Ministry of Innovation and Science for a Ph.D. grant.es_ES
dc.publisherSpringer Verlages_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherMass spectrometryes_ES
dc.titleBiological responses related to agonistic, antagonistic and synergistic interactions of chemical specieses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Spanish Ministry of Science and Education (MEC) [CTM2009-12858-C02-01]es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Innovation, Science and Enterprise Agency (Andalusian Government) [P08-FQM-03554, P09-FQM-4659]

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