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dc.contributor.authorGonzález Domínguez , Raúl 
dc.contributor.authorGarcía Barrera, Tamara 
dc.contributor.authorVitorica, Javier
dc.contributor.authorGómez Ariza, José Luis
dc.identifier.citationGonzález Domínguez, R., García Barrera, T., Vitorica, J., Gómez Ariza, J.L.: "Metabolomic research on the role of interleukin-4 in Alzheimer’s disease". Metabolomics. Vol. 11, n, 5, págs. 1175–1183, (2015). DOI: 10.1007/s11306-015-0773-zes_ES
dc.identifier.issn1573-3890 (electrónico)
dc.description.abstractInflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral system. Thus, modulation of inflammation in animal models of this neurodegenerative disorder may be of great interest to elucidate the pathological mechanisms underlying this inflammatory component. To this end, a metabolomic investigation on a triple transgenic mouse model obtained by crossing the APP/PS1 mice with interleukin-4 knockout mice (a model of impaired immune function) was performed for the first time. Serum samples from transgenic mice and wild type animals were analyzed by direct infusion mass spectrometry followed by multivariate statistics in order to identify altered metabolites. Subsequently, metabolic pathway analysis allowed the elucidation of potential pathological mechanisms associated with the development of Alzheimer-type disorders in response to interleukin-4 deficiency, such as impaired homeostasis of histamine, altered metabolism of amino acids (threonine, aspartate and tyrosine), deregulated urea cycle and increased production of eicosanoids. Therefore, this work demonstrates the potential of this triple transgenic model with modulated immunity for the study of pathological mechanisms associated with inflammation in Alzheimer’s disease.es_ES
dc.description.sponsorshipThis work was supported by the Projects CTM2012-38720-C03-01 from the Ministerio de Ciencia e Innovacion, and projects P012-FQM-0442 and P009-FQM-4659 from the Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia). Raul Gonzalez Dominguez thanks the Ministerio de Educacion for a predoctoral scholarship.es_ES
dc.publisherSpringer Verlages_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherAPP/PS1 micees_ES
dc.subject.otherDirect infusion mass spectrometryes_ES
dc.subject.otherAlzheimer’s diseasees_ES
dc.titleMetabolomic research on the role of interleukin-4 in Alzheimer’s diseasees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Ministerio de Ciencia e Innovacion [CTM2012-38720-C03-01]es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia) [P012-FQM-0442, P009-FQM-4659]

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