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dc.contributor.authorGonzález Domínguez, Raúl
dc.contributor.authorGarcía Barrera, Tamara 
dc.contributor.authorVitorica, Javier
dc.contributor.authorGómez Ariza, José Luis 
dc.date.accessioned2018-04-10T08:19:30Z
dc.date.available2018-04-10T08:19:30Z
dc.date.issued2015
dc.identifier.citationGonzález Domínguez, R., García Barrera, T., Vitorica, J., Gómez Ariza, J.L.: "Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches". Biochimie. Vol. 110, págs. 119-128, (2015). DOI: 10.1016/j.biochi.2015.01.005es_ES
dc.identifier.issn0300-9084
dc.identifier.issn1638-6183 (electrónico)
dc.identifier.urihttp://hdl.handle.net/10272/14592
dc.description.abstractThe transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological and cognitive deficits observed in human Alzheimer's disease. In this study, serum samples from APP/PS1 mice (n = 30) and wild-type controls (n = 30) were analyzed using a metabolomic multiplatform based on the combination of gas chromatography-mass spectrometry and ultra-high performance liquid chromatography-mass spectrometry, in order to obtain wide information about serum metabolome. Metabolic profiles showed significant differences between the groups of study, and numerous metabolites were identified as potential players in the development of Alzheimer-type disorders in this transgenic model. Pathway analysis revealed the involvement of multiple metabolic networks in the underlying pathology, such as deficiencies in energy metabolism, altered amino acid homeostasis, abnormal membrane lipid metabolism, and other impairments related to the integrity of the central nervous system. It is noteworthy that some of these metabolomic markers are in accordance with pathological alterations observed in human Alzheimer's disease, while others have not been previously described. Therefore, these results demonstrate the potential of metabolomics and the use of transgenic animal models to understand the pathogenesis of Alzheimer's disease.es_ES
dc.description.sponsorshipThis work was supported by the projects CTM2012-38720-C03-01 from the Ministerio de Ciencia e Innovacion and P009-FQM-4659 from the Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia). Raul Gonzalez Dominguez thanks the Ministerio de Educacion for a predoctoral scholarship.
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.otherMetabolomicses_ES
dc.subject.otherAPP/PS1es_ES
dc.subject.otherAlzheimer's diseasees_ES
dc.subject.otherSerumes_ES
dc.titleDeciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approacheses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.biochi.2015.01.005es_ES
dc.identifier.doi10.1016/j.biochi.2015.01.005
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Ministerio de Ciencia e Innovacion [CTM2012-38720-C03-01]
dc.relation.projectIDinfo:eu-repo/grantAgreement/Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia) [P009-FQM-4659]


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