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dc.contributor.authorGonzález Domínguez, Raúl
dc.contributor.authorGarcía Barrera, Tamara 
dc.contributor.authorGómez Ariza, José Luis
dc.identifier.citationGonzález Domínguez, R., García Barrera, T., Gómez Ariza, J.L.: "Homeostasis of metals in the progression of Alzheimer's disease". BioMetals. Vol. 27, n. 3, págs. 539–549, (2014). DOI: 10.1007/s10534-014-9728-5
dc.identifier.issn1572-8773 (electrónico)
dc.description.abstractIn order to study the involvement of metals in the progression of Alzheimer's disease, serum samples from patients with Alzheimer and mild cognitive impairment were investigated. For this purpose, metal content was analyzed after size-fractionation of species and then, inter-element and inter-fraction ratios were computed. In this way, the analysis allowed discovering changes that could be used as markers of disease, but also provided a new insight into the interactions in the homeostasis of elements in neurodegeneration and its progression. Aluminum and labile forms of iron and copper were increased in demented patients, while manganese, zinc and selenium were reduced. Interestingly, levels of different elements, principally iron, aluminum and manganese, were closely inter-related, which could evidence a complex interdependency between the homeostasis of the different metals in this disorder. On the other hand, imbalances in metabolism of copper, zinc and selenium could be associated to abnormal redox status. Therefore, this study may contribute to our understanding of the pathological mechanisms related to metals in Alzheimer's disease.es_ES
dc.description.sponsorshipThis work was supported by the projects CTM2012-38720-C03-01 from the Ministerio de Ciencia e Innovacion and P008-FQM-3554 and P009-FQM-4659 from the Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia). Raul Gonzalez Dominguez thanks the Ministerio de Educacion for a predoctoral scholarship. The authors also thank to Dr. Alberto Blanco and Carlos Salgado from Hospital Juan Ramon Jimenez for providing serum samples.es_ES
dc.publisherSpringer Verlages_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject.otherAlzheimer’s diseasees_ES
dc.subject.otherMild cognitive impairmentes_ES
dc.subject.otherMetal homeostasises_ES
dc.subject.otherInter-element relationses_ES
dc.titleHomeostasis of metals in the progression of Alzheimer's diseasees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/Ministerio de Ciencia e Innovacion [CTM2012-38720-C03-01]
dc.relation.projectIDinfo:eu-repo/grantAgreement/Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia) [P008-FQM-3554, P009-FQM-4659]

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