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dc.contributor.authorGómez Acebo, Inés
dc.contributor.authorCamacho, Antonio
dc.contributor.authorLlorca, Javier
dc.date.accessioned2017-02-21T09:16:32Z
dc.date.available2017-02-21T09:16:32Z
dc.date.issued2016
dc.identifier.citationGómez Acebo, I., Camacho, A., Llorca, J... [et al.]: "The use of antihypertensive medication and the risk of breast cancer in a case-control study in a Spanish population : the MCCSpain study". PLoS ONE. 11(8), (2016). DOI: 10.1371/journal.pone.0159672en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10272/13348
dc.description.abstractIntroduction The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. Methods In this case-control study, we report the antihypertensive drugs–breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women’s characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs. Results The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk. Conclusions In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women).en_US
dc.description.sponsorshipThe study was partially funded by the "Accion Transversal del Cancer" project, approved by the Spanish Council of Ministers on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-Leon, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219), by the Fundacion Marques de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economia y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Tematica de Investigacion del Cancer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y Leon (LE22A10-2), by the Consejeria de Salud of the Junta de Andalucia (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation and by the Catalan Government DURSI grant 2009SGR1489.en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleThe use of antihypertensive medication and the risk of breast cancer in a case-control study in a Spanish population : the MCCSpain studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1371/journal.pone.0159672
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/ICGC International Cancer Genome Consortium CLL (Spanish Ministerio de Economia y Competitividad (MINECO) through Red Tematica de Investigacion del Cancer (RTICC) del ISCIII) [RD12/0036/0036]en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/Consejeria de Salud of the Junta de Andalucia [2009-S0143]
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission [FOOD-CT-2006-036224-HIWATE]


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