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dc.contributor.authorBenítez Burraco, Antonio 
dc.contributor.authorMurphy, Elliot
dc.date.accessioned2016-04-18T09:50:20Z
dc.date.available2016-04-18T09:50:20Z
dc.date.issued2016
dc.identifier.citationBenítez Burraco, A., Murphy, E.: "The oscillopathic nature of language deficits in autism : from genes to language evolution". Frontiers in Human Neuroscience. Vol. 10, article 120, (2016). DOI: 10.3389/fnhum.2016.00120en_US
dc.identifier.issn1662-5161
dc.identifier.urihttp://hdl.handle.net/10272/11926
dc.description.abstractAutism spectrum disorders (ASD) are pervasive neurodevelopmental disorders involving a number of deficits to linguistic cognition. The gap between genetics and the pathophysiology of ASD remains open, in particular regarding its distinctive linguistic profile. The goal of this article is to attempt to bridge this gap, focusing on how the autistic brain processes language, particularly through the perspective of brain rhythms. Due to the phenomenon of pleiotropy, which may take some decades to overcome, we believe that studies of brain rhythms, which are not faced with problems of this scale, may constitute a more tractable route to interpreting language deficits in ASD and eventually other neurocognitive disorders. Building on recent attempts to link neural oscillations to certain computational primitives of language, we show that interpreting language deficits in ASD as oscillopathic traits is a potentially fruitful way to construct successful endophenotypes of this condition. Additionally, we will show that candidate genes for ASD are overrepresented among the genes that played a role in the evolution of language. These genes include (and are related to) genes involved in brain rhythmicity. We hope that the type of steps taken here will additionally lead to a better understanding of the comorbidity, heterogeneity, and variability of ASD, and may help achieve a better treatment of the affected populations.en_US
dc.description.sponsorshipPreparation of this work was supported in part by funds from the Spanish Ministry of Economy and Competitiveness (grant numbers FFI-2013-43823-P and FFI2014-61888-EXP to AB-B). This work was also supported by an Economic and Social Research Council scholarship (1474910). The authors would also like to thank the two reviewers for their valuable comments.
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.otherAutismen_US
dc.subject.otherNeural oscillationsen_US
dc.subject.otherRUNX2en_US
dc.subject.otherEvo-devoen_US
dc.subject.otherBiolinguisticsen_US
dc.subject.otherLanguage evolutionen_US
dc.titleThe oscillopathic nature of language deficits in autism : from genes to language evolutionen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.3389/fnhum.2016.00120
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/Spanish Ministry of Economy and Competitiveness [FFI-2013-43823-P, FFI2014-61888-EXP]


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