Regioselective Formation of 2,5-Disubstituted Oxazoles Via Copper(I)-Catalyzed Cycloaddition of Acyl Azides and 1-Alkynes
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Publication Date
2011 -
Publisher
American Chemical Society -
Citation
Cano. I.. Álvarez, E., Nicasio Jaramillo, M.C., Pérez Romero, P.J.: "Regioselective Formation of 2,5-Disubstituted Oxazoles Via Copper(I)-Catalyzed Cycloaddition of Acyl Azides and 1-Alkynes". Journal of the American Chemical Society. Vol 133, págs. 191-193, (2011). DOI: 10.1021/ja109732s -
Abstract
The reaction of 1-alkynes with acylazides in the presence of [Tpm*,BrCu(NCMe)]BF4 (Tpm*,Br = tris(3,5-dimethyl-4-bromopyrazolyl)methane) as the catalyst provides 2,5-oxazoles in moderate to high yields. This is a novel transformation of CuAAC type, that constitutes a significant variation of the commonly observed [3+2] cycloaddition reaction to yield 1,2,3-triazoles -
Project
info:eu-repo/grantAggreement/MEC [Proyecto CTQ2008-00042/BQU, CSD2006-003]
info:eu-repo/grantAggreement/Junta de Andalucia [Proyecto P07-FQM-02745]
Fichero | Tamaño | Formato |
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Regioselective_formation.pdf | 631.4Kb | View/ | versión post-print |
Fichero | Tamaño | Formato |
| Description |
---|---|---|---|---|
Regioselective_formation.pdf | 631.4Kb | View/ | versión post-print |